• 09 FEB 10
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    #1213:Belyaev – Microwaves From Mobile Phones Inhibit 53BP1 Focus Formation in Human Stem Cells

    From Cindy Sage (as posted on the cheemf list):

    A landmark paper by Igor Belayev’s team at Stockholm University has
    reported that very low intensity microwave radiation from mobile phones
    inhibits DNA repair processes in human stem cells.

    By placing a mobile phone at one meter distance from human stem cells
    in petri dishes (SAR = 0.037 W/Kg), they found a significant reduction in
    53BP1 foci. These foci are a measure of DNA repair in cells with double
    strand DNA damage. The damage was greater to stem cells (derived from adipose
    tissue in humans) than in fibroblasts (differentiated cells). Stem cells did not
    adapt over time – and the damage was done within one hour of MW exposure.
    Fibroblast cells were similarly affected (inhibited 52BP1 foci) but adapted over time.

    The effects are carrier-frequency dependent. The effects occurred with GSM
    exposure at 915 MHz, but not at 905 MHz. The failure to produce DNA repair
    also occurred at the mobile phone UTMS carrier frequency of 1947 MHz.

    Analysis of 53BP1 foci is the most sensitive technique to measure double-strand
    DNA breaks in both unexposed cells and in cells exposued to cytotoxic agents.

    In the authors’ words, “this represents a direct mechanistic link to epidemiological
    data showing an association of MW exposure with increased cancer risk.” The
    date obtained from human stem cells is of “utmost relevance for assessment
    of possible health risks of MW exposure from mobile phones.” Most, if not all
    adult tissues and organs including blood, skin and brain contain stem cells.
    Therefore, “stem cells like blood cells and fibroblasts are always subjected to
    exposure from mobile phones.”

    With respect to children, because “almost all organs and tissues possess stem cells and stem
    cells are more active in children, the possible relationship of chronic MW exposure and
    various types of tumors and leukemia especially in children should be investigated.”

    Perhaps this accounts for the Hardell et al data that report children are more at risk
    from mobile phone use than adults, where the risk of glioma is more than 5-fold in
    children but just more than 2-fold in adults.

    Submitted by Cindy Sage

    Markova E Malmgren LOG Belyaev IY. Microwaves from mobile phones inhibit 53PB1 focus
    formation in human stem cells stronger than in differentiated cells: Possible mechanistic
    link to cancer risk. Environmental Health Perspectives On-line 22 October 2009.
    doi:10.1289/ehp.0900781

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