• 14 NOV 06
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    #586: Limitations of the Interphone Study

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    #586: Limitations of the Interphone Study

    Here is a recent report from the INTERPHONE study. Note the conclusions on the limitations of the Interphone study to detect any increases brain tumours, etc. from cell phone use. Very convenient for the cell phone industry.


    Occup Environ Med. 2006 Apr;63(4):237-43.
    Validation of short term recall of mobile phone use for the Interphone study.

    Vrijheid M, Cardis E, Armstrong BK, Auvinen A, Berg G, Blaasaas KG, Brown J, Carroll M, Chetrit A, Christensen HC, Deltour I, Feychting M, Giles GG, Hepworth SJ, Hours M, Iavarone I, Johansen C, Klaeboe L, Kurttio P, Lagorio S, Lonn S, McKinney PA, Montestrucq L, Parslow RC, Richardson L, Sadetzki S, Salminen T, Schuz J, Tynes T, Woodward A; Interphone Study Group. International Agency for Research on Cancer, Lyon, France. vrijheid@iarc.fr

    AIM: To validate short term recall of mobile phone use within Interphone, an international collaborative case control study of tumours of the brain, acoustic nerve, and salivary glands related to mobile telephone use. METHODS: Mobile phone use of 672 volunteers in 11 countries was recorded by operators or through the use of software modified phones, and compared to use recalled six months later using the Interphone study questionnaire. Agreement between recalled and actual phone use was analysed using both categorical and continuous measures of number and duration of phone calls.

    RESULTS: Correlations between recalled and actual phone use were moderate to high (ranging from 0.5 to 0.8 across countries) and of the same order for number and duration of calls. The kappa statistic demonstrated fair to moderate agreement for both number and duration of calls (weighted kappa ranging from 0.20 to 0.60 across countries). On average, subjects underestimated the number of calls per month (geometric mean ratio of recalled to actual = 0.92, 95% CI 0.85 to 0.99), whereas duration of calls was overestimated (geometric mean ratio = 1.42, 95% CI 1.29 to 1.56). The ratio of recalled to actual use increased with level of use, showing underestimation in light users and overestimation in heavy users. There was substantial heterogeneity in this ratio between countries. Inter-individual variation was also large, and increased with level of use.

    CONCLUSIONS: Volunteer subjects recalled their recent phone use with moderate systematic error and substantial random error. This large random error can be expected to reduce the power of the Interphone study to detect an increase in risk of brain, acoustic nerve, and parotid gland tumours with increasing mobile phone use, if one exists.

    INTERPHONE-Study. [J Expo Anal Environ Epidemiol. 2005] Mobile phone use and risk of acoustic neuroma: results of the Interphone case-control study in five North European countries.
    [Br J Cancer. 2005]

    The effects of recall errors and of selection bias in epidemiologic studies of mobile phone use and cancer risk. [J Expo Sci Environ Epidemiol. 2006]
    Validation of self-reported cellular phone use. [J Expo Anal Environ
    Epidemiol. 2004] Recall of past use of mobile phone
    handsets. [Radiat Prot Dosimetry. 2003]

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